USP6

Across TCGA patient cohorts, USP6 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP6-associated genes across cancer lineages are FASN, 4E-BP1, and eEF2. Each is linked with USP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP6-to-partner and partner-to-USP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by USP6-low versus USP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP6→partner) and Y-score (partner→USP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.355	+1.523	<.001	.006	3	3
UCEC	4E-BP1 →	+0.373	+2.247	<.001	<.001	3	3
UCEC	eEF2 →	+0.280	+1.343	.003	.002	3	2
SKCM	ERK2 →	+0.211	+1.847	.002	.007	3	2
UCEC	Heregulin →	-0.084	-1.723	.010	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.164	-1.489	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

FASN by USP6 expression — UCEC

Explore this box plot interactively →