USP53

Across TCGA patient cohorts, USP53 mutation is significantly associated with the RNA expression of many other genes, with 5,544 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP53-associated genes across cancer lineages are EZH2P1, NARF, and SYNJ2BP-COX16. Each is linked with USP53 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP53-to-partner and partner-to-USP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EZH2P1 grouped by USP53-low versus USP53-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP53→partner) and Y-score (partner→USP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	EZH2P1 →	+0.157	+3.975	.004	.006	3	3
UCEC	NARF →	+0.367	+3.617	<.001	.001	3	3
UCEC	SYNJ2BP-COX16 →	+0.164	+2.174	.004	.002	3	3
HNSC	GJE1 →	+0.025	+4.339	.002	.007	3	2
UCEC	COPS8P1 →	+0.081	+2.237	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.451	+1.815	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,544 associations by consensus.

EZH2P1 by USP53 expression — CESC

Explore this box plot interactively →