USP51

Across TCGA patient cohorts, USP51 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP51-associated genes across cancer lineages are Cyclin-E1, FOXO3a_pS318_S321, and TFRC. Each is linked with USP51 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP51-to-partner and partner-to-USP51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by USP51-low versus USP51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP51→partner) and Y-score (partner→USP51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E1 →	+0.316	+2.700	.040	.006	3	3
UCEC	FOXO3a_pS318_S321 →	-0.100	-1.575	.023	.034	3	2
UCEC	TFRC →	+0.422	+1.362	.024	.037	3	2
UCEC	TIGAR →	+0.137	+1.689	.010	.007	3	2
UCEC	ATM →	-0.397	-1.807	.013	.025	3	2
UCEC	Cyclin-B1 →	+0.684	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-E1 by USP51 expression — UCEC

Explore this box plot interactively →