USP51

Across TCGA pan-cancer cohorts, USP51 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP51’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP51 RNA is repressed in tumor relative to normal tissue. In most cancer types USP51 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where USP51 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP51 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.363	<.001	11	view →
LUAD	Male	III,IV	−0.920	<.001	9	view →
COAD	Male	II,III,IV	−0.515	<.001	9	view →
UCEC	All	All	−1.227	<.001	6	view →
BLCA	Male	IV	−1.732	<.001	5	view →
KIRC	Male	II,III,IV	−0.387	.002	5	view →
BRCA	Female	All	−0.353	<.001	4	view →
READ	All	All	−0.933	.002	2	view →
KIRP	All	All	−0.454	.024	2	view →
STAD	All	All	−0.439	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP51–THCA

Open the THCA breakdown →