USP50

Across TCGA patient cohorts, USP50 mutation is significantly associated with the RNA expression of many other genes, with 2,269 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP50-associated genes across cancer lineages are TXNL4AP1, MIR6803, and RNU6-42P. Each is linked with USP50 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP50-to-partner and partner-to-USP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4AP1 grouped by USP50-low versus USP50-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP50→partner) and Y-score (partner→USP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL4AP1 →	+0.295	+4.366	<.001	<.001	3	3
UCEC	MIR6803 →	+0.217	+5.156	<.001	<.001	3	2
COAD	RNU6-42P →	+1.017	+3.842	<.001	.005	3	2
COAD	TRAJ12 →	+1.339	+4.140	<.001	.002	3	2
COAD	IGHD2-2 →	+1.866	+3.771	.001	.006	3	2
COAD	NFYBP1 →	+0.321	+3.897	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,269 associations by consensus.

TXNL4AP1 by USP50 expression — COAD

Explore this box plot interactively →