USP49

Across TCGA cell cohorts, USP49 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP49-associated genes across cancer lineages are CNGA3, GPR101, and ELSPBP1. Each is linked with USP49 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP49-to-partner and partner-to-USP49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGA3 grouped by USP49-low versus USP49-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP49→partner) and Y-score (partner→USP49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CNGA3 →	+0.036	+4.807	<.001	.006	3	1
OVARY	GPR101 →	+0.016	+4.990	<.001	.001	3	1
OVARY	ELSPBP1 →	+0.146	+4.029	.003	.009	3	1
OVARY	FAM205C →	+0.079	+5.339	<.001	<.001	3	1
OVARY	STH →	+0.131	+4.228	<.001	.006	3	1
OVARY	OR13C5 →	+0.018	+5.339	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

CNGA3 by USP49 expression — BLOOD_Myeloma

Explore this box plot interactively →