USP48

Across TCGA patient cohorts, USP48 mutation is significantly associated with the RNA expression of many other genes, with 5,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP48-associated genes across cancer lineages are ENSAP3, RNU4-50P, and MIR3128. Each is linked with USP48 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP48-to-partner and partner-to-USP48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENSAP3 grouped by USP48-low versus USP48-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP48→partner) and Y-score (partner→USP48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ENSAP3 →	+0.176	+4.343	<.001	.001	3	3
LUAD	RNU4-50P →	+1.040	+3.847	<.001	.005	3	3
READ	MIR3128 →	+1.142	+4.626	<.001	.004	3	3
LUAD	OR2D3 →	+0.115	+3.453	.002	.009	3	3
LUAD	RNU5E-3P →	+1.054	+4.315	<.001	.007	3	3
THCA	NBEAP3 →	+0.030	+5.078	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,284 associations by consensus.

ENSAP3 by USP48 expression — LUAD

Explore this box plot interactively →