USP46

Across TCGA pan-cancer cohorts, USP46 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP46 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher USP46 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USP46 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and COAD are the cancer types where USP46 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.200	0.913	<.001	28	view →
UCEC	DFS	Median	All	0.936	0.619	.013	24	view →
COAD	OS	Median	All	0.168	0.799	.004	15	view →
ESCA	OS	Median	II,III,IV	0.311	0.689	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP46–BRCA (OS)

Open the BRCA breakdown →