USP46

Across TCGA pan-cancer cohorts, USP46 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of USP46’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USP46 RNA is repressed in tumor relative to normal tissue. In most cancer types USP46 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where USP46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.043	<.001	11	view →
KICH	Male	II,III,IV	−1.687	<.001	10	view →
KIRP	Male	All	−1.011	<.001	9	view →
LIHC	Female	II,III,IV	+0.847	<.001	9	view →
THCA	Male	II,III,IV	−0.812	<.001	9	view →
LUSC	Female	All	+1.025	<.001	7	view →
CHOL	Male	All	+1.854	<.001	5	view →
BRCA	All	II,III,IV	+0.356	<.001	4	view →
COAD	Male	All	+0.319	.012	3	view →
BLCA	Female	III,IV	+0.604	.030	2	view →
LUAD	Female	II,III,IV	−0.316	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

USP46–KIRC

Open the KIRC breakdown →