USP46

Across TCGA pan-cancer cohorts, USP46 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated USP46 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher USP46 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated USP46 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and UCEC are the cancer types where USP46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.921	0.709	.003	19	view →
GBM	DFS	Quartile	All	0.546	0.267	.014	9	view →
UCEC	OS	Median	All	0.962	0.865	.037	6	view →
PDAC	OS	Quartile	All	0.682	0.336	.019	5	view →
CCRCC	OS	Median	All	0.588	1.000	.046	2	view →
HNSC	DFS	Tertile	IV	0.894	0.580	.044	2	view →
LSCC	DFS	Median	All	0.448	0.836	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

USP46–LUAD (OS)

Open the LUAD breakdown →