USP46

Across TCGA patient cohorts, USP46 protein abundance is significantly associated with the RNA expression of many other genes, with 9,363 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible USP46-associated genes across cancer lineages are SLC43A3, BTBD7, and EFCC1. Each is linked with USP46 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP46-to-partner and partner-to-USP46 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP46 versus SLC43A3 in OV, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP46→partner) and Y-score (partner→USP46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC43A3 →	-0.817	-0.510	.006	<.001	3	5
BRCA	BTBD7 →	+0.555	+0.336	<.001	.002	3	3
OV	EFCC1 →	+1.002	+0.445	<.001	<.001	3	3
BRCA	KIAA1109 →	+0.628	+0.303	<.001	<.001	3	3
BRCA	SRD5A1 →	-0.724	-0.379	.007	.005	3	3
BRCA	CXCL13 →	-1.804	-0.361	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,363 associations by consensus.

USP46 vs SLC43A3 — OV

Explore this scatter interactively →