USP46

Across TCGA cell cohorts, USP46 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP46-associated genes across cancer lineages are BANF2, CST9, and ADIPOQ. Each is linked with USP46 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP46-to-partner and partner-to-USP46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by USP46-low versus USP46-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP46→partner) and Y-score (partner→USP46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.096	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	CST9 →	+0.060	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ADIPOQ →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	CYLC1 →	+0.029	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

BANF2 by USP46 expression — BLOOD_Lymphoma

Explore this box plot interactively →