USP45

Across TCGA pan-cancer cohorts, USP45 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP45 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher USP45 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP45 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

CESC, BRCA, and LIHC are the cancer types where USP45 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.188	0.785	.001	12	view →
BRCA	OS	Median	III,IV	0.335	0.833	.011	12	view →
LIHC	OS	Median	II,III,IV	0.011	0.716	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.925	0.435	.017	8	view →
STAD	DFS	Median	II,III,IV	1.000	0.358	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP45–CESC (DFS)

Open the CESC breakdown →