USP45

Across TCGA cell cohorts, USP45 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,578 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP45-associated GO terms across cancer lineages are 7-methylguanosine RNA capping, 7-methylguanosine mRNA capping, and Mismatch repair. Each is linked with USP45 in more than 16 cancer types. Because this analysis shows association rather than direction, both USP45-to-partner and partner-to-USP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 7-methylguanosine RNA capping grouped by USP45-low versus USP45-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP45→partner) and Y-score (partner→USP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	7-methylguanosine RNA capping →	+0.132	+0.789	<.001	<.001	3	17
OVARY	7-methylguanosine mRNA capping →	+0.132	+0.789	<.001	<.001	3	17
LARGE_INTESTINE	Mismatch repair →	+0.080	+0.815	<.001	<.001	3	16
LIVER	Positive regulation of chromosome organization →	+0.062	+0.774	<.001	<.001	3	15
LIVER	Mitotic spindle assembly →	+0.086	+0.457	<.001	.002	3	14
LUNG_SCLC	'de novo' AMP biosynthetic process →	+0.141	+0.606	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,578 associations by consensus.

7-methylguanosine RNA capping by USP45 expression — OVARY

Explore this box plot interactively →