USP45

Across TCGA cell cohorts, USP45 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP45-associated genes across cancer lineages are Mirin, Leflunomide, and GSK2801. Each is linked with USP45 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP45-to-partner and partner-to-USP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by USP45-low versus USP45-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP45→partner) and Y-score (partner→USP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.412	+2.646	.029	.047	3	1
LARGE_INTESTINE	Leflunomide →	+0.269	+2.769	.036	.040	3	1
LARGE_INTESTINE	GSK2801 →	+0.363	+2.649	.021	.046	3	1
LARGE_INTESTINE	50869 →	+0.470	+2.678	.025	.037	3	1
LARGE_INTESTINE	Ara-G →	+0.174	+2.722	.039	.040	3	1
LARGE_INTESTINE	IWP-2 →	+0.283	+2.893	.033	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Mirin by USP45 expression — LARGE_INTESTINE

Explore this box plot interactively →