USP44

Across TCGA pan-cancer cohorts, USP44 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP44 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher USP44 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated USP44 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, SCLC, and BLCA are the cancer types where USP44 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.481	.016	28	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
BLCA	OS	Median	All	0.207	0.618	.020	12	view →
CESC	OS	Median	All	0.110	0.588	.024	6	view →
LUAD	DFS	Median	All	0.207	0.656	.012	6	view →
SKCM	OS	Median	All	0.834	0.309	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP44–UCEC (DFS)

Open the UCEC breakdown →