USP43

Across TCGA pan-cancer cohorts, USP43 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated USP43 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher USP43 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP43 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where USP43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.925	0.476	.002	26	view →
LUAD	OS	Median	All	0.984	0.937	.015	7	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.935	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

USP43–UCEC (DFS)

Open the UCEC breakdown →