USP43

Across TCGA patient cohorts, USP43 protein abundance is significantly associated with the RNA expression of many other genes, with 7,398 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP43-associated genes across cancer lineages are PKIA, RIN1, and AKT3-IT1. Each is linked with USP43 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP43-to-partner and partner-to-USP43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP43 versus PKIA in HNSC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP43→partner) and Y-score (partner→USP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PKIA →	-0.997	-0.330	.002	.003	3	3
LSCC	RIN1 →	+0.749	+0.362	.001	.002	3	3
HNSC	AKT3-IT1 →	-1.171	-0.514	<.001	<.001	3	3
LSCC	BACH2 →	-0.527	-0.333	.001	.001	3	3
UCEC	LRP11 →	+0.660	+0.379	<.001	.001	3	3
LSCC	EGR2 →	-0.720	-0.459	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,398 associations by consensus.

USP43 vs PKIA — HNSC

Explore this scatter interactively →