USP43

Across TCGA patient cohorts, USP43 mutation is significantly associated with the RNA expression of many other genes, with 1,750 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP43-associated genes across cancer lineages are NF2, ATP1B2, and PCAT19. Each is linked with USP43 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP43-to-partner and partner-to-USP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by USP43-low versus USP43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP43→partner) and Y-score (partner→USP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.422	+2.545	<.001	<.001	3	3
UCEC	ATP1B2 →	-0.663	-2.989	.001	<.001	3	3
UCEC	PCAT19 →	-0.787	-2.313	.001	.001	3	3
LUSC	MIR5088 →	+0.463	+5.882	<.001	.002	3	3
BLCA	RNY4P24 →	+0.554	+3.423	<.001	.006	3	2
BLCA	SNORA41B →	+0.178	+5.040	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,750 associations by consensus.

NF2 by USP43 expression — UCEC

Explore this box plot interactively →