USP43

Across TCGA patient cohorts, USP43 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP43-associated genes across cancer lineages are 4E-BP1, p27_pT198, and INPP4B. Each is linked with USP43 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP43-to-partner and partner-to-USP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by USP43-low versus USP43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP43→partner) and Y-score (partner→USP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.283	+2.584	.003	.010	3	3
SKCM	p27_pT198 →	+0.158	+2.476	.001	.009	3	2
UCEC	INPP4B →	-0.244	-1.678	.032	.019	3	2
UCEC	PDCD4 →	-0.532	-1.668	.001	.021	3	2
UCEC	ATM →	-0.703	-2.906	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.533	+2.242	.010	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

4E-BP1 by USP43 expression — UCEC

Explore this box plot interactively →