USP41

Across TCGA patient cohorts, USP41 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP41-associated genes across cancer lineages are FoxM1, Notch1, and STAT3_pY705. Each is linked with USP41 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP41-to-partner and partner-to-USP41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by USP41-low versus USP41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP41→partner) and Y-score (partner→USP41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.361	+3.169	.011	.020	3	1
UCEC	Notch1 →	+0.249	+3.169	.001	.020	3	1
UCEC	STAT3_pY705 →	-0.570	-3.159	<.001	.019	3	1
UCEC	VHL →	-0.968	-3.169	.009	.019	3	1
UCEC	Cyclin-B1 →	+0.787	+3.169	.010	.020	2	1
UCEC	mTOR_pS2448 →	-0.251	-3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by USP41 expression — UCEC

Explore this box plot interactively →