USP41

Across TCGA cell cohorts, USP41 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,551 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP41-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Regulation of type I interferon-mediated signaling pathway, and Positive regulation of type I interferon production. Each is linked with USP41 in more than 12 cancer types. Because this analysis shows association rather than direction, both USP41-to-partner and partner-to-USP41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by USP41-low versus USP41-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP41→partner) and Y-score (partner→USP41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Transcription pausing by RNA polymerase II →	+0.152	+3.185	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of type I interferon-mediated signaling pathway →	+0.160	+2.619	<.001	<.001	3	12
BLOOD_Lymphoma	Positive regulation of type I interferon production →	+0.075	+2.419	<.001	<.001	3	12
KIDNEY	Antiviral innate immune response →	+0.107	+2.692	.003	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.074	+2.386	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of Golgi inheritance →	+0.158	+2.877	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,551 associations by consensus.

Transcription pausing by RNA polymerase II by USP41 expression — LIVER

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