USP36

Across TCGA pan-cancer cohorts, USP36 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP36 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP36 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated USP36 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where USP36 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.478	0.796	.011	16	view →
GBM	OS	Quartile	All	0.588	0.345	.005	8	view →
PDAC	DFS	Quartile	All	0.689	0.948	.032	7	view →
LSCC	OS	Quartile	All	0.909	0.674	.038	1	view →
LUAD	OS	Tertile	All	0.654	0.913	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP36–CCRCC (OS)

Open the CCRCC breakdown →