USP35

Across TCGA pan-cancer cohorts, USP35 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP35 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher USP35 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP35 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where USP35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.485	0.812	.046	2	view →
HNSC	OS	Quartile	All	0.889	0.556	.047	2	view →
PDAC	DFS	Quartile	II,III,IV	0.930	0.497	.024	2	view →
LSCC	DFS	Median	II,III,IV	1.000	0.586	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP35–LUAD (DFS)

Open the LUAD breakdown →