USP33

Across TCGA cell cohorts, USP33 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible USP33-associated genes across cancer lineages are AVP, C18orf63, and OR2M4. Each is linked with USP33 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP33-to-partner and partner-to-USP33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by USP33-low versus USP33-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP33→partner) and Y-score (partner→USP33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	C18orf63 →	+0.019	+4.867	<.001	.009	3	1
OVARY	OR2M4 →	+0.055	+3.700	.001	.005	3	1
OVARY	OR4C6 →	+0.127	+3.791	<.001	.007	3	1
OVARY	OR2H1 →	+0.016	+4.444	.005	.001	3	1
OVARY	OR2J3 →	+0.017	+3.938	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AVP by USP33 expression — BLOOD_Lymphoma

Explore this box plot interactively →