USP31

Across TCGA pan-cancer cohorts, USP31 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP31 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher USP31 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP31 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where USP31 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.387	0.976	.040	5	view →
LSCC	OS	Quartile	III,IV	1.000	0.454	.040	5	view →
CCRCC	DFS	Quartile	II,III,IV	0.403	0.920	.040	5	view →
UCEC	DFS	Median	All	1.000	0.825	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP31–LUAD (DFS)

Open the LUAD breakdown →