USP31

Across TCGA pan-cancer cohorts, USP31 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of USP31’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where USP31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP31 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and COAD are the cancer types where USP31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.106	<.001	12	view →
KIRP	All	II,III,IV	+0.921	<.001	11	view →
COAD	All	III,IV	+0.909	<.001	11	view →
KIRC	All	All	+0.354	<.001	10	view →
LIHC	Male	All	+0.775	<.001	9	view →
LUSC	Female	All	+1.437	<.001	7	view →
STAD	All	II,III,IV	+0.723	.002	6	view →
BRCA	Female	All	−0.388	<.001	6	view →
READ	All	All	+0.662	.001	5	view →
CHOL	Male	All	+1.266	<.001	4	view →
BLCA	All	III,IV	+0.891	.021	3	view →
UCEC	All	All	−0.730	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

USP31–HNSC

Open the HNSC breakdown →