USP31

Across TCGA patient cohorts, USP31 mutation is significantly associated with the RNA expression of many other genes, with 5,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP31-associated genes across cancer lineages are RFC5, PSMD9, and PSMB2. Each is linked with USP31 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP31-to-partner and partner-to-USP31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by USP31-low versus USP31-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP31→partner) and Y-score (partner→USP31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC5 →	+0.567	+3.348	<.001	.005	3	5
SKCM	PSMD9 →	+0.333	+1.879	<.001	.004	3	5
STAD	PSMB2 →	+0.363	+3.347	.003	.004	3	5
STAD	AURKB →	+0.646	+2.239	.009	.005	3	5
UCEC	ALYREF →	+0.484	+1.847	.001	<.001	3	5
UCEC	NCAPG →	+0.698	+1.680	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,229 associations by consensus.

RFC5 by USP31 expression — COAD

Explore this box plot interactively →