USP31

Across TCGA patient cohorts, USP31 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP31-associated genes across cancer lineages are PCNA, ATM, and Claudin-7. Each is linked with USP31 in more than 4 cancer types. Because this analysis shows association rather than direction, both USP31-to-partner and partner-to-USP31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by USP31-low versus USP31-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP31→partner) and Y-score (partner→USP31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.292	+3.321	.015	.009	2	5
UCEC	ATM →	-0.552	-1.947	<.001	<.001	3	4
STAD	Claudin-7 →	+0.703	+3.459	.010	.004	3	3
UCEC	Cyclin-B1 →	+0.576	+1.700	<.001	.001	3	3
SKCM	Akt →	-0.332	-1.807	.008	.026	3	3
SKCM	PRDX1 →	+0.331	+3.321	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

PCNA by USP31 expression — STAD

Explore this box plot interactively →