USP31

Across TCGA cell cohorts, USP31 mutation is significantly associated with the RNA expression of many other genes, with 753 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP31-associated genes across cancer lineages are GUCY2D, OR10W1, and SERPINA7. Each is linked with USP31 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP31-to-partner and partner-to-USP31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCY2D grouped by USP31-low versus USP31-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP31→partner) and Y-score (partner→USP31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GUCY2D →	+0.104	+4.064	<.001	.003	3	2
BREAST	OR10W1 →	+0.013	+5.781	<.001	.001	3	2
LUNG_SCLC	SERPINA7 →	+0.057	+4.817	<.001	.001	3	2
BLOOD_Myeloma	C4orf17 →	+0.032	+4.000	<.001	.002	3	1
BLOOD_Myeloma	DUOXA2 →	+0.043	+3.514	.001	.008	3	1
BLOOD_Myeloma	CYP8B1 →	+0.024	+3.832	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 753 associations by consensus.

GUCY2D by USP31 expression — SOFT_TISSUE

Explore this box plot interactively →