USP30

Across TCGA pan-cancer cohorts, USP30 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP30 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP30 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP30 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where USP30 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.349	0.819	.001	61	view →
PDAC	DFS	Quartile	All	0.293	0.695	.002	34	view →
HNSC	OS	Quartile	All	0.706	1.000	.012	8	view →
GBM	OS	Tertile	All	0.334	0.630	.042	4	view →
LUAD	OS	Tertile	II,III,IV	0.893	0.467	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP30–CCRCC (DFS)

Open the CCRCC breakdown →