USP30

Across TCGA cell cohorts, USP30 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP30-associated genes across cancer lineages are KRT73, OR6Q1, and C4orf50. Each is linked with USP30 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP30-to-partner and partner-to-USP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT73 grouped by USP30-low versus USP30-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP30→partner) and Y-score (partner→USP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT73 →	+0.066	+4.196	.003	.002	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1
SKIN	C4orf50 →	+0.022	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KRT73 by USP30 expression — LARGE_INTESTINE

Explore this box plot interactively →