USP30-AS1

Across TCGA pan-cancer cohorts, USP30-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated USP30-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher USP30-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated USP30-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, CESC, and OV are the cancer types where USP30-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.423	0.260	<.001	136	view →
CESC	OS	Quartile	All	0.905	0.676	<.001	64	view →
OV	OS	Median	All	0.379	0.281	.006	60	view →
LGG	DFS	Median	All	0.670	0.797	<.001	50	view →
THYM	DFS	Tertile	All	0.402	0.868	.001	36	view →
LAML	DFS	Median	All	0.351	0.571	.003	36	view →
BRCA	OS	Median	All	0.628	0.529	.002	33	view →
BLCA	OS	Median	III,IV	0.705	0.599	.008	33	view →
ACC	OS	Median	II,III,IV	0.766	0.413	.002	33	view →
UVM	DFS	Tertile	All	0.359	0.726	.003	29	view →
HNSC	DFS	Median	All	0.686	0.563	.005	27	view →
READ	DFS	Median	II,III,IV	0.882	0.708	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

USP30-AS1–SKCM (OS)

Open the SKCM breakdown →