USP30-AS1

Across TCGA pan-cancer cohorts, USP30-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of USP30-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USP30-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP30-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where USP30-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP30-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.232	<.001	11	view →
LUAD	Female	III,IV	−1.778	<.001	9	view →
LUSC	Male	II,III,IV	−1.766	<.001	8	view →
COAD	Female	All	−1.347	<.001	8	view →
HNSC	Male	All	+0.853	<.001	5	view →
ESCA	All	II,III,IV	+2.375	.030	4	view →
KIRP	All	All	+0.485	.009	4	view →
BRCA	All	All	+0.430	<.001	4	view →
THCA	Male	IV	+1.450	.008	3	view →
STAD	Female	All	+1.284	.026	3	view →
CHOL	Male	All	−1.593	.019	2	view →
KICH	Female	II,III,IV	−0.714	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

USP30-AS1–KIRC

Open the KIRC breakdown →