USP3

Across TCGA patient cohorts, USP3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP3-associated genes across cancer lineages are ATM, INPP4B, and p62 Lck ligand. Each is linked with USP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP3-to-partner and partner-to-USP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP3-low versus USP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP3→partner) and Y-score (partner→USP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.697	-4.169	<.001	<.001	3	3
UCEC	INPP4B →	-0.296	-1.700	.023	.042	3	2
UCEC	p62 Lck ligand →	+0.276	+1.906	.035	.016	3	2
UCEC	PCNA →	+0.250	+2.321	.004	.033	3	2
UCEC	c-Kit →	-0.216	-1.906	.021	.016	3	2
UCEC	EGFR_pY1173 →	+0.095	+1.512	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by USP3 expression — UCEC

Explore this box plot interactively →