USP3

Across TCGA pan-cancer cohorts, USP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated USP3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher USP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP3 expression acts as an unfavorable survival marker, although some lineages such as LGG and BLCA show a favorable association.

ACC, LGG, and BLCA are the cancer types where USP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.261	0.659	<.001	70	view →
LGG	OS	Median	All	0.939	0.848	<.001	33	view →
BLCA	DFS	Median	All	0.682	0.547	<.001	28	view →
KIRP	DFS	Tertile	IV	0.138	0.667	.010	24	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	23	view →
PAAD	DFS	Quartile	All	0.193	0.532	.005	22	view →
KICH	DFS	Quartile	III,IV	0.079	1.000	.003	22	view →
LIHC	OS	Median	All	0.718	0.830	.004	21	view →
LAML	DFS	Tertile	All	0.422	0.720	.008	18	view →
BRCA	DFS	Median	All	0.459	0.609	.006	18	view →
GBM	DFS	Tertile	All	0.469	0.210	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

USP3–ACC (DFS)

Open the ACC breakdown →