USP3

Across TCGA cell cohorts, USP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,360 significant associations in total. CNS shows the largest number of these associations.

The most reproducible USP3-associated GO terms across cancer lineages are Granzyme-mediated apoptotic signaling pathway, Symbiont-mediated disruption of host cell PML body, and Amelogenesis. Each is linked with USP3 in more than 8 cancer types. Because this analysis shows association rather than direction, both USP3-to-partner and partner-to-USP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Granzyme-mediated apoptotic signaling pathway grouped by USP3-low versus USP3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP3→partner) and Y-score (partner→USP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Granzyme-mediated apoptotic signaling pathway →	+0.059	+0.453	<.001	<.001	3	8
PANCREAS	Symbiont-mediated disruption of host cell PML body →	+0.086	+0.592	<.001	.005	2	9
CNS	Amelogenesis →	-0.230	-0.517	<.001	.002	3	7
PANCREAS	Dentinogenesis →	-0.898	-0.511	.002	.001	3	7
LARGE_INTESTINE	Apoptotic cell clearance →	-0.147	-0.824	<.001	<.001	3	7
BONE	Regulation of viral budding via host ESCRT complex →	+0.111	+0.482	.008	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,360 associations by consensus.

Granzyme-mediated apoptotic signaling pathway by USP3 expression — CNS

Explore this box plot interactively →