USP3

Across TCGA cell cohorts, USP3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP3-associated genes across cancer lineages are GUCY2F, TBR1, and C9orf153. Each is linked with USP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP3-to-partner and partner-to-USP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCY2F grouped by USP3-low versus USP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP3→partner) and Y-score (partner→USP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCY2F →	+0.007	+3.103	.007	.004	3	1
LARGE_INTESTINE	TBR1 →	+0.059	+3.333	<.001	.009	3	1
LARGE_INTESTINE	C9orf153 →	+0.226	+3.497	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

GUCY2F by USP3 expression — LARGE_INTESTINE

Explore this box plot interactively →