USP26

Across TCGA patient cohorts, USP26 mutation is significantly associated with the RNA expression of many other genes, with 4,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP26-associated genes across cancer lineages are LSM3P3, COX4I2, and MDH1. Each is linked with USP26 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP26-to-partner and partner-to-USP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM3P3 grouped by USP26-low versus USP26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP26→partner) and Y-score (partner→USP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSM3P3 →	+0.245	+1.215	.004	.008	3	4
UCEC	COX4I2 →	-0.574	-1.542	.005	.001	3	4
UCEC	MDH1 →	+0.309	+1.617	.004	<.001	3	4
COAD	NDC80 →	+0.643	+3.332	.001	.005	3	4
STAD	AUNIP →	+0.649	+3.207	.006	.009	3	4
UCEC	CENPM →	+0.614	+2.237	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,568 associations by consensus.

LSM3P3 by USP26 expression — UCEC

Explore this box plot interactively →