USP26

Across TCGA pan-cancer cohorts, USP26 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated USP26 data layer compared with 6 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher USP26 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP26 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THCA show a favorable association.

BRCA, KIRC, and LIHC are the cancer types where USP26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	II,III,IV	0.854	0.915	.003	76	view →
KIRC	OS	Tertile	All	0.506	0.666	.002	62	view →
LIHC	OS	Tertile	All	0.519	0.720	<.001	60	view →
ESCA	OS	Tertile	III,IV	0.667	0.278	.002	39	view →
ACC	OS	Tertile	All	0.184	0.644	.008	36	view →
LUSC	DFS	Tertile	II,III,IV	0.601	0.759	.002	34	view →
SCLC	OS	Tertile	All	0.306	0.542	.018	15	view →
PCPG	OS	Tertile	All	0.896	0.985	.011	15	view →
THCA	OS	Tertile	III,IV	1.000	0.780	.016	15	view →
PAAD	OS	Tertile	All	0.517	0.644	.028	12	view →
SKCM	OS	Tertile	II,III,IV	0.751	0.860	.015	12	view →
UCS	OS	Quartile	All	0.304	0.636	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

USP26–BRCA (DFS)

Open the BRCA breakdown →