USP26

Across TCGA cell cohorts, USP26 mutation is significantly associated with the RNA expression of many other genes, with 456 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP26-associated genes across cancer lineages are KLHL40, SPATA19, and CLDN34. Each is linked with USP26 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP26-to-partner and partner-to-USP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by USP26-low versus USP26-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP26→partner) and Y-score (partner→USP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KLHL40 →	+0.016	+3.481	<.001	.004	3	2
BLOOD_Myeloma	SPATA19 →	+0.033	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
CNS	RSPH6A →	+0.021	+3.874	.007	.006	3	1
CNS	HHLA1 →	+0.023	+4.906	<.001	<.001	3	1
CNS	C17orf98 →	+0.043	+4.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 456 associations by consensus.

KLHL40 by USP26 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →