USP21

Across TCGA cell cohorts, USP21 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,066 significant associations in total. BONE shows the largest number of these associations.

The most reproducible USP21-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nucleic acid catabolic process, and Negative regulation of gene expression, epigenetic. Each is linked with USP21 in more than 16 cancer types. Because this analysis shows association rather than direction, both USP21-to-partner and partner-to-USP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by USP21-low versus USP21-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP21→partner) and Y-score (partner→USP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.078	+1.210	.002	.001	3	17
STOMACH	Nucleic acid catabolic process →	+0.068	+0.912	<.001	<.001	3	16
OVARY	Negative regulation of gene expression, epigenetic →	+0.066	+0.589	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.071	+1.059	<.001	<.001	3	16
STOMACH	Positive regulation of double-strand break repair via homologous recombination →	+0.083	+0.697	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.100	+1.062	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,066 associations by consensus.

Epigenetic regulation of gene expression by USP21 expression — BONE

Explore this box plot interactively →