USP21

Across TCGA cell cohorts, USP21 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP21-associated genes across cancer lineages are GHRHR, FAM216B, and MORN5. Each is linked with USP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP21-to-partner and partner-to-USP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by USP21-low versus USP21-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP21→partner) and Y-score (partner→USP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.370	+3.705	<.001	.007	3	1
BLOOD_Leukemia	FAM216B →	+0.141	+3.944	<.001	.006	3	1
BLOOD_Leukemia	MORN5 →	+0.219	+3.855	<.001	.007	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+3.874	<.001	.005	3	1
BLOOD_Leukemia	GOLGA6L1 →	+0.027	+4.060	<.001	.003	3	1
OVARY	KRTAP4-5 →	+0.086	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GHRHR by USP21 expression — BLOOD_Leukemia

Explore this box plot interactively →