USP20

Across TCGA patient cohorts, USP20 mutation is significantly associated with the RNA expression of many other genes, with 2,442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP20-associated genes across cancer lineages are RN7SKP264, MIA-RAB4B, and IPPK. Each is linked with USP20 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP20-to-partner and partner-to-USP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP264 grouped by USP20-low versus USP20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP20→partner) and Y-score (partner→USP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP264 →	+0.192	+2.062	<.001	<.001	3	3
UCEC	MIA-RAB4B →	+0.059	+1.583	<.001	.002	3	3
UCEC	IPPK →	+0.344	+1.890	.003	.004	3	3
UCEC	VARS2 →	+0.361	+2.069	.001	<.001	3	3
UCEC	SKA1 →	+0.732	+2.069	<.001	<.001	3	3
UCEC	ORC5 →	+0.336	+1.777	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,442 associations by consensus.

RN7SKP264 by USP20 expression — UCEC

Explore this box plot interactively →