USP19

Across TCGA patient cohorts, USP19 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP19-associated genes across cancer lineages are NF-kB-p65_pS536, PKC-b-II_pS660, and eIF4E. Each is linked with USP19 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP19-to-partner and partner-to-USP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by USP19-low versus USP19-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP19→partner) and Y-score (partner→USP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NF-kB-p65_pS536 →	-0.484	-3.000	.030	.034	3	3
COAD	PKC-b-II_pS660 →	-0.441	-3.169	.002	.018	3	3
UCEC	eIF4E →	+0.250	+3.058	<.001	<.001	3	2
COAD	INPP4B →	-0.611	-3.691	<.001	.001	3	2
COAD	MIG-6 →	+0.126	+3.760	.002	<.001	3	2
COAD	PAI-1 →	+0.844	+2.593	<.001	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

NF-kB-p65_pS536 by USP19 expression — COAD

Explore this box plot interactively →