USP19

Across TCGA pan-cancer cohorts, USP19 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of USP19’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USP19 RNA is repressed in tumor relative to normal tissue. In most cancer types USP19 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where USP19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.817	<.001	11	view →
THCA	All	III,IV	−0.613	<.001	10	view →
LIHC	Female	II,III,IV	+0.915	<.001	9	view →
CHOL	All	All	+0.935	<.001	5	view →
BRCA	Female	All	−0.292	<.001	4	view →
KICH	All	All	−0.640	<.001	3	view →
UCEC	All	All	−0.546	.002	2	view →
KIRP	Male	All	−0.446	.003	2	view →
STAD	Male	II,III,IV	+0.634	.028	1	view →
BLCA	Male	IV	−0.552	.009	1	view →
HNSC	Male	IV	−0.349	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

USP19–KIRC

Open the KIRC breakdown →