USP19

Across TCGA cell cohorts, USP19 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP19-associated genes across cancer lineages are CSH1, DEFB125, and TLE6. Each is linked with USP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP19-to-partner and partner-to-USP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSH1 grouped by USP19-low versus USP19-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP19→partner) and Y-score (partner→USP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CSH1 →	+0.039	+3.339	<.001	.006	3	2
BLOOD_Leukemia	DEFB125 →	+0.025	+3.475	<.001	.006	3	2
LARGE_INTESTINE	TLE6 →	+1.010	+3.295	<.001	.003	3	2
LARGE_INTESTINE	KXD1 →	+0.361	+2.588	.004	.004	3	2
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR8B12 →	+0.074	+3.734	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

CSH1 by USP19 expression — BLOOD_Leukemia

Explore this box plot interactively →