USP17L4

Across TCGA patient cohorts, USP17L4 RNA expression is significantly associated with the protein abundance of many other proteins, with 2,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP17L4-associated proteins across cancer lineages are NUCKS1_S75, PCNT_S3242, and RTN1_S350. Each is linked with USP17L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP17L4-to-partner and partner-to-USP17L4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP17L4 versus NUCKS1_S75 in CCRCC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USP17L4→partner) and Y-score (partner→USP17L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NUCKS1_S75 →	+0.889	+0.135	.003	.004	3	2
PDAC	PCNT_S3242 →	-0.495	-0.121	.003	<.001	3	2
GBM	RTN1_S350 →	+0.697	+0.185	.001	.001	3	2
UCEC	TP53BP1_S640 →	+0.436	+0.150	.002	.004	3	2
GBM	FAM98B →	+0.208	+0.241	.001	<.001	3	2
UCEC	LEO1_S220 →	+0.882	+0.211	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,126 associations by consensus.

USP17L4 vs NUCKS1_S75 — CCRCC

Explore this scatter interactively →