USP17L4

Across TCGA pan-cancer cohorts, USP17L4 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated USP17L4 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher USP17L4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP17L4 expression acts as an unfavorable survival marker.

ESCA, THCA, and SKCM are the cancer types where USP17L4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	All	0.255	0.557	<.001	90	view →
THCA	DFS	Tertile	All	0.087	0.868	<.001	63	view →
SKCM	DFS	Tertile	III,IV	0.044	0.616	<.001	63	view →
OV	OS	Tertile	IV	0.022	0.760	<.001	36	view →
LGG	OS	Tertile	All	0.255	0.810	.001	36	view →
READ	DFS	Tertile	All	0.112	0.845	.001	36	view →
BLCA	OS	Tertile	IV	0.051	0.600	<.001	36	view →
THYM	DFS	Tertile	All	0.049	0.811	.005	18	view →
LUAD	OS	Tertile	All	0.235	0.697	.031	18	view →
SARC	OS	Tertile	All	0.299	0.771	.003	18	view →
KIRC	OS	Tertile	II,III,IV	0.438	0.723	.039	12	view →
LAML	DFS	Tertile	All	0.379	0.586	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

USP17L4–ESCA (DFS)

Open the ESCA breakdown →