USP16

Across TCGA patient cohorts, USP16 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP16-associated genes across cancer lineages are eIF4E, NDRG1_pT346, and PDCD4. Each is linked with USP16 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP16-to-partner and partner-to-USP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by USP16-low versus USP16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP16→partner) and Y-score (partner→USP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.155	+2.713	.016	.003	3	3
UCEC	NDRG1_pT346 →	-0.305	-1.415	.042	.040	3	2
UCEC	PDCD4 →	-0.383	-1.064	.007	.048	3	2
UCEC	Rad50 →	-0.188	-2.308	.011	.005	3	2
UCEC	cIAP →	+0.088	+1.594	.035	.021	3	2
UCEC	4E-BP1 →	+0.280	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by USP16 expression — UCEC

Explore this box plot interactively →